The prognostic significance of circulating and disseminated tumor cells in patients with colorectal cancer is controversial.
Dr Nuh Rahbari and colleagues from Germany performed a meta-analysis of available studies to assess whether the detection of tumor cells in the blood and bone marrow of patients diagnosed with primary colorectal cancer can be used as a prognostic factor.
The team searched the Medline, Biosis, Science citation index and Embase databases and reference lists of relevant articles for studies that assessed the prognostic relevance of tumor cell detection in the peripheral blood and mesenteric/portal blood, or bone marrow of patients with colorectal cancer.
|A total of 36 studies including 3094 patients were studied|
The researchers assessed a total of 36 studies, including 3094 patients, were eligible for final analyses.
Pooled analyses that combined all sampling sites associated the detection of tumor cells with poor recurrence-free survival and overall survival.
The research team found that detection of tumor cells in the peripheral blood compartment was a statistically significant prognostic factor, but not in the mesenteric/portal blood or in the bone marrow.
Dr Rahbari's team concluded, “Detection of colorectal cancer tumor cells in the peripheral blood indicates poor prognosis in patients with primary colorectal cancer.”