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 22 November 2017

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News

Depression is associated with GERD

Depression and treatment with antidepressants are associated with the development of gastro-esophageal reflux disease, finds the latest issue of the Alimentary Pharmacology & Therapeutics.

News image

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The roles of depression and antidepressants in triggering reflux symptoms remain unclear.

Dr Martin-Merino and colleagues from Spain compared the incidence of gastro-esophageal reflux disease in individuals with and without a depression diagnosis, and evaluated risk factors for a gastro-esophageal reflux disease diagnosis.

The relationship between antidepressant treatment and gastro-oesophageal reflux disease was also assessed.

The research team used the health improvement network UK primary care database to identify patients with incident depression and an age- and sex-matched control cohort with no depression diagnosis.

GERD incidence was 14 per 1000 person-years in the depression cohort
Alimentary Pharmacology & Therapeutics

Incident gastro-esophageal reflux disease diagnoses were identified during a mean follow-up of 3 years.

The researchers performed nested case-control analyses where odds ratios with 95% confidence intervals were estimated by unconditional logistic regression in multivariable models.

The team found that the incidence of gastro-esophageal reflux disease was 14 per 1000 person-years in the depression cohort, and 8 per 1000 person-years in the control cohort.

The hazard ratio of gastro-esophageal reflux disease in patients with depression compared with controls was 1.7.

Among patients with depression, tricyclic antidepressant use was associated with an increased risk of gastro-esophageal reflux disease, while selective serotonin reuptake inhibitors were not associated with gastro-esophageal reflux disease.

Dr Martin-Merino's team concluded, “A depression diagnosis is associated with an increased risk of a subsequent gastro-esophageal reflux disease diagnosis, particularly in individuals using tricyclic antidepressants.”

Aliment Pharmacol Ther 2010: 31(10): 1132-40
30 April 2010

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