The roles of depression and antidepressants in triggering reflux symptoms remain unclear.
Dr Martin-Merino and colleagues from Spain compared the incidence of gastro-esophageal reflux disease in individuals with and without a depression diagnosis, and evaluated risk factors for a gastro-esophageal reflux disease diagnosis.
The relationship between antidepressant treatment and gastro-oesophageal reflux disease was also assessed.
The research team used the health improvement network UK primary care database to identify patients with incident depression and an age- and sex-matched control cohort with no depression diagnosis.
|GERD incidence was 14 per 1000 person-years in the depression cohort|
|Alimentary Pharmacology & Therapeutics|
Incident gastro-esophageal reflux disease diagnoses were identified during a mean follow-up of 3 years.
The researchers performed nested case-control analyses where odds ratios with 95% confidence intervals were estimated by unconditional logistic regression in multivariable models.
The team found that the incidence of gastro-esophageal reflux disease was 14 per 1000 person-years in the depression cohort, and 8 per 1000 person-years in the control cohort.
The hazard ratio of gastro-esophageal reflux disease in patients with depression compared with controls was 1.7.
Among patients with depression, tricyclic antidepressant use was associated with an increased risk of gastro-esophageal reflux disease, while selective serotonin reuptake inhibitors were not associated with gastro-esophageal reflux disease.
Dr Martin-Merino's team concluded, “A depression diagnosis is associated with an increased risk of a subsequent gastro-esophageal reflux disease diagnosis, particularly in individuals using tricyclic antidepressants.”