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Acute pancreatitis is rare during pregnancy.
Limited data are available about maternal and fetal outcomes.
Dr Shou–Jiang Tang and colleagues investigated the effects of acute pancreatitis during pregnancy on fetal outcome.
The team performed at a single academic center, included 96 consecutive pregnant women who presented with, and 7 developed acute pancreatitis in the hospital in 2000–2006.
Patient histories and clinical data were collected from medical records.
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| Term pregnancy was achieved in 80% of patients |
| Clinical Gastroenterology & Hepatology |
The researchers found that of the 96 patients with spontaneous pancreatitis, 4 had complications.
Of these, 1 patient in the first trimester had acute peripancreatic fluid collection, and 3 patients in the third trimester developed disseminated vascular coagulation.
None of these patients achieved term pregnancy, and 1 of the patients with disseminated vascular coagulation died.
Endoscopic retrograde cholangiopancreatography was performed in 23 patients with acute pancreatitis.
The research team diagnosed post-endoscopic retrograde cholangiopancreatography pancreatitis in 4 patients.
Term pregnancy was achieved in 80% of patients.
Patients who developed pancreatitis in the first trimester had the lowest percentage of term pregnancy, and highest risks of fetal loss, and preterm delivery.
Of the patients with pancreatitis in the second and third trimesters, only one had fetal loss.
The researchers observed no fetal malformations.
Dr Tang's team concluded, “The majority of pregnant patients with acute pancreatitis did not have complications."
"Most adverse fetal outcomes occurred during the first trimester.”
“Acute pancreatitis, complicated by disseminated vascular coagulation, occurred most frequently in the third trimester and was associated with poor fetal and maternal outcomes.”
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