Help
Subscribe


Rodes Read For FREE - Our full range of review articles
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Guido Tytgat Profile of Pete Peterson Profile of Emmet Keeffe Profile of Peter Cotton Profile of Roy Pounder

Home

News  
Profiles
Journals
Review Articles
Slide Atlas
Video Clips
Systematic Reviews
Meta-analyses
Guidelines
Online Books
Advanced Digestive Endoscopy
Lectures
Classical Cases
Personal View
Quiz
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links
APT cover
Free Journal Trial

the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Cost-effectiveness of different oral antiviral therapies in chronic Hepatitis B

A study in the latest issue of the Journal of Hepatology models the cost-effectiveness of different oral antiviral therapies in patients with chronic hepatitis B.

News image

Chronic hepatitis B is a common disease associated with high morbidity, mortality and impact on healthcare costs.
 
Several oral antiviral therapies can lead to complete virologic response, which is associated with prevention of disease progression.

Dr Maria Buti and colleagues from Spain estimated the cost-effectiveness of the oral antiviral treatments lamivudine, adefovir, telbiv patients treated with one of the above drugs or no treatment.

Rescue therapy with 2 different combination therapies (adefovir plus lamivudine or tenofovir plus entecavir) with their corresponding costs and efficacy rates was also considered.

The probabilities of disease progression were based on serum Hepatitis B virus DNA levels.

Disease and complication costs were assessed using the perspective of the Spanish National Health System.
The highest rate of virologic response was obtained with tenofovir
Journal of Hepatology

The researchers found that the highest rate of virologic response was obtained with tenofovir.

This translated to its higher life years saved and quality adjusted life years compared with the rest of the alternatives in Hepatitis B e antigen-positive and Hepatitis B e anitigen-negative patients.

Tenofovir is associated with lower costs and higher efficacy over entecavir, telbivudine and adefovir in Hepatitis B e antigen-positive patients, and telbivudine and entecavir in Hepatitis B e antigen-negative patients.

The incremental cost-effectiveness ratios with respect to the rest of the alternatives are below the common reference efficiency threshold of 30,000€ per life years saved /quality adjusted life years.

Dr Buti's team concluded, “In chronic HBV infected patients, tenofovir is a cost-effective or even cost-saving strategy compared with other available treatment options for chronic hepatitis B.”

J Hepatol 2009: 51(4): 640-46
23 September 2009

Go to top of page Email this page Email this page to a colleague

 09 February 2010

Advanced search
 09 February 2010 
Reflux in wind instrument players
 09 February 2010 
Diagnosis of ulcerative colitis and disease severity
 09 February 2010 
Screening of migrants for chronic hep B
 08 February 2010 
Early treatment in acute hep C
 08 February 2010 
Hospital access variations for colorectal cancer
 08 February 2010 
Body image after colorectal cancer surgery
 05 February 2010 
Aging of Hep C-infected persons in the USA
 05 February 2010 
Quality of life after liver transplants
 05 February 2010 
Risk factors for IBD
 04 February 2010 
Survival for non-hep C-related liver transplants
 04 February 2010 
Nonemergency vs emergency colorectal operations
 04 February 2010 
GERD in asthma and COPD
 03 February 2010 
Rotavirus vaccination and mortality in diarrhea
 03 February 2010 
Treatment of childhood obesity
 03 February 2010 
Dietary management of functional GI symptoms
 02 February 2010 
Oral medications with significant hepatic metabolism
 02 February 2010 
Human rotavirus vaccine for diarrhea
 02 February 2010 
Diabetes risk after pancreas transplant
 01 February 2010 
Outcomes for adult living liver donors
 01 February 2010 
Quality of life in pediatric liver transplants
 01 February 2010 
Elevated liver function tests and survival
 29 January 2010 
Survival after transplant in hepatopulmonary syndrome
 29 January 2010 
Folate intake and pancreatic cancer
 29 January 2010 
Hep B among refugees in the USA
 28 January 2010 
Bypass and GERD in obesity
 28 January 2010 
Changes after laparoscopic fundoplication for GERD
 28 January 2010 
Diet and risk of gastric adenocarcinoma
 27 January 2010 
BMI and mortality
 27 January 2010 
Pancreatitis during pregnancy
 27 January 2010 
Dietary fiber and obesity prevention
 26 January 2010 
High body mass index in US children
 26 January 2010 
Insulin resistance and colorectal cancer risk
 26 January 2010 
Hospitalizations in minority patients with IBD
 25 January 2010 
Nonvariceal upper GI bleeding
 25 January 2010 
Treating IBS
 25 January 2010 
Obesity among US adults
 22 January 2010 
Predicting recurrence in Crohn's after resection
 22 January 2010 
Monoclonal antibodies against C. difficile
 22 January 2010 
Pneumococcal polysaccharide vaccination in IBD
 21 January 2010 
Pyogenic liver abscesses in the USA
 21 January 2010 
H pylori in peptic ulcer disease
 21 January 2010 
Evaluation of endoscopic activity in ulcerative colitis
 20 January 2010 
Quality of life in cirrhosis
 20 January 2010 
Colorectal cancer risk after colonoscopy
 20 January 2010 
C. diff in patients with cirrhosis
 19 January 2010 
Upper GI findings in heartburn where PPIs failed
 19 January 2010 
Diagnostic accuracy of tests in colorectal cancer
 19 January 2010 
Mortality in peptic ulcer bleeding
 18 January 2010 
Yield of Barrett's by endoscopy
 18 January 2010 
Treatment of H. pylori
 18 January 2010 
Cardiovascular riks in liver transplant patients
 15 January 2010 
Validation of intra-abdominal pressure
 15 January 2010 
Predictor of mortality in colorectal cancer
 15 January 2010 
Predicting mortality in HIV liver transplants
 14 January 2010 
Colorectal cancer in Barrett's esophagus
 14 January 2010 
Shared decision-making in treating IBD
 14 January 2010 
Laparoscopic versus open resection in the elderly
 13 January 2010 
Liver transplants in alcoholic liver disease
 13 January 2010 
Adolescents with NAFLD
 13 January 2010 
Hospital admissions after fundoplication in children

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2010 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us