Visceral fat accumulation reportedly increases the risk of hepatocellular carcinoma development in patients with chronic liver disease.
It has not been fully elucidated whether visceral fat accumulation increases the risk of hepatocellular carcinoma recurrence after curative treatment in patients with suspected non-alcoholic steatohepatitis (NASH).
Dr Ohki and colleagues from Japan enrolled 62 patients with naïve hepatocellular carcinoma with suspected non-alcoholic steatohepatitis.
All were curatively treated with percutaneous radiofrequency ablation between 1999 and 2006.
The visceral fat area was determined in each patient from CT images, taken at the time of hepatocellular carcinoma diagnosis.
The team divided patients into two groups based on visceral fat area: the high visceral fat area group and the others.
|Recurrence rates were 75% at 3 years in the high visceral fat area group|
The effects of visceral fat area on hepatocellular carcinoma recurrence were analyzed.
Other factors including patients’ background, tumor-related factors and liver function-related factors were evaluated.
The researchers found the cumulative recurrence rates differed significantly between the two groups.
The recurrence rates were 16%, 57% and 75% at 1, 2 and 3 years, respectively, in the high visceral fat area group, and 10%, 31% and 43%, respectively, in the controls.
Multivariate analysis indicated visceral fat accumulation, and older age as independent risk factors of hepatocellular carcinoma recurrence.
Dr Ohki's team concluded, “Visceral fat accumulation is an independent risk factor of hepatocellular carcinoma recurrence after curative treatment in patients with suspected non-alcoholic steatohepatitis.”