Liver biopsies detect silent donor disease in potential living liver donors and provide material for studies of subclinical non-alcoholic fatty liver disease.
Dr Marta Minervini and colleagues from Italy determined the contribution of biopsy findings to potential donor evaluation.
Factors contributing to pre-clinical non-alcoholic fatty liver disease and correlations between liver injury tests and histopathology have been also determined.
Patient records, laboratory tests and results of the histopathologic examination and diagnoses of 284 patients from 2001 to 2005 were retrospectively extracted from the EDIT database.
|Only 42% of biopsies from the study population were completely normal|
|Journal of Hepatology|
Hepatic histology was correlated with liver injury tests and with general demographic characteristics in an otherwise normal healthy population.
The team noted that only 42% of biopsies from this population of 143 males, and 141 females were completely normal.
The remainder showed steatosis, steatohepatitis, or unexplained low-grade/early stage chronic hepatitis, primary biliary cirrhosis, or nodular regenerative hyperplasia.
Biopsy findings disqualified 29 out of 56 donors.
Independent risk factors for non-alcoholic fatty liver disease by multivariate modeling, which differed by sex, and included body mass index, age, iron, and alanine aminotransferase.
Dr Minervini’s team commented, “Liver biopsies provide valuable information about otherwise undetectable liver disease in potential liver donors.”
“Obesity, age and iron, which are influenced by sex, contribute to non-alcoholic fatty liver disease pathogenesis.”
“Blood tests other than standard liver profiles are needed to detect early non-alcoholic fatty liver disease.”