Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 24 November 2017

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Ready-to-use therapeutic foods reduce mortality in young children

The latest issue of the Journal of the American Medical Association examines the effect of preventive supplementation with ready-to-use therapeutic foods in children in Niger.

News image

fiogf49gjkf04

Ready-to-use therapeutic foods are an important component of effective outpatient treatment of severe wasting.

However, their effectiveness in the population-based prevention of moderate and severe wasting has not been evaluated.

Dr Sheila Isanaka and colleagues evaluated the effect of a 3-month distribution of ready-to-use therapeutic foods on the nutritional status, mortality, and morbidity of children aged 6 to 60 months in Niger.

The team conducted a cluster randomized trial of 12 villages in Maradi, Niger.

The adjusted effect of the intervention from baseline to the end of follow-up was thus 0.22 z
Journal of the American Medical Association

The research team randomized 6 villages to intervention, and 6 to no intervention.

All children in the study villages aged 6 to 60 months were eligible for recruitment.

Children with weight-for-height 80% or more of the National Center for Health Statistics reference median in the 6 intervention villages received a monthly distribution of 1 packet per day of ready-to-use therapeutic foods in 2006.

Children in the 6 nonintervention villages received no preventive supplementation.

Active surveillance for conditions requiring medical or nutritional treatment was conducted monthly in all 12 study villages from 2006 to 2007.

The team's main outcome measures included changes in weight-for-height z score according to the World Health Organization Child Growth Standards and incidence of wasting over 8 months of follow-up.

The research team found that the number of children with height and weight measurements in August, October, December, and February was 3166, 3110, 2936, and 3026, respectively.

The difference between the intervention and nonintervention groups was -0.10 z at baseline and 0.12 z after 8 months of follow-up.

The adjusted effect of the intervention from baseline to the end of follow-up was 0.22 z.

The team found that the absolute rate of wasting and severe wasting, respectively, was 0.17 events per child-year, and 0.03 events per child-year in the intervention villages.

In the non-intervention villages, the absolute rate of wasting and severe wasting was 0.26 events per child-year, and 0.07 events per child-year.

The intervention thus resulted in a 36% reduction in the incidence of wasting, and a 58% reduction in the incidence of severe wasting.

There was no reduction in mortality, with a mortality rate of 0.01 deaths per child-year in the intervention villages and 0.02 deaths per child-year in the nonintervention villages.

Dr Isanaka's team commented, "Short-term supplementation of nonmalnourished children with ready-to-use therapeutic foods reduced the decline in the weight-for-height z score, and the incidence of wasting and severe wasting over 8 months."

JAMA 2009: 301(3): 277-85


26 January 2009

Go to top of page Email this page Email this page to a colleague

 24 November 2017 
Osteoporotic fractures in Barrett's esophagus
 24 November 2017 
Center ERCP volume and procedure success
 24 November 2017 
Adipokines and IBD
 23 November 2017 
Pharmacological management of GERD
 23 November 2017 
Incidence of biopsy-verified celiac disease
 23 November 2017 
Distance travelling for rectal cancer outcomes
 22 November 2017 
Challenges of US-trained gastroenterologists when abroad
 22 November 2017 
Surgical treatment delays influence survival in colon cancer
 22 November 2017 
Golimumab in Crohn's disease
 21 November 2017 
Preoperative optimization in IBD patients
 21 November 2017 
Cholangiopathy in critically ill patients
 21 November 2017 
Prepregnancy obesity and maternal mortality
 20 November 2017 
Barriers to hepatitis C treatment
 20 November 2017 
Socioeconomic characteristics in diverticular disease
 20 November 2017 
Endoscopic indices of disease activity for Crohn’s
 17 November 2017 
Food elimination diets for treatment of adults with eosinophilic esophagitis
 17 November 2017 
PPI use and cognitive function in women
 17 November 2017 
Predicting microscopic colitis
 16 November 2017 
NAFLD-hepatocellular carcinoma and survival after orthotopic liver transplant
 16 November 2017 
Prepregnancy obesity and severe maternal morbidity
 16 November 2017 
Celiac disease screening in adult first-degree relatives
 15 November 2017 
Breastfeeding and the risk of IBD
 15 November 2017 
Predicting recurrence after curative rectal cancer surgery
 15 November 2017 
Medication nonadherence and health care costs
 14 November 2017 
Eosinophilic gastroenteritis and colitis
 14 November 2017 
HBV/HCV coinfection and cirrhosis
 14 November 2017 
Sexual dysfunction after rectal cancer surgery
 13 November 2017 
Genetic polymorphisms, fatty acids and ulcerative colitis
 13 November 2017 
Flares after immunomodulator withdrawal in Crohn's
 13 November 2017 
GI bleeding in patients taking non–vitamin K antagonist oral anticoagulants
 10 November 2017 
Thiopurines vs TNF and lymphoma risk in IBD
 10 November 2017 
Drug monitoring of anti-tumour necrosis factor therapy in IBD
 10 November 2017 
Treatment decisions for older patients with colorectal cancer
 09 November 2017 
Quality standards in upper gastrointestinal endoscopy
 09 November 2017 
Irradiated rectal cancer and chemoradiotherapy
 09 November 2017 
Environmental factors and IBD
 08 November 2017 
Prophylaxis of spontaneous bacterial peritonitis
 08 November 2017 
Optimal management of postoperative Crohn's disease
 07 November 2017 
Community Screening for Helicobacter pylori
 07 November 2017 
Early readmission in IBD patients
 07 November 2017 
Mesocolic excision for colon cancer
 06 November 2017 
Food elimination diet for children with eosinophilic esophagitis
 06 November 2017 
Biologic agents and obesity in children with IBD
 06 November 2017 
Liver cancer burden despite extensive use of antiviral agents
 03 November 2017 
Statins and mortality in chronic viral hepatitis
 03 November 2017 
Propofol for outpatient colonoscopy
 03 November 2017 
Asthma and IBD development
 02 November 2017 
Diverticulitis and emergency department burden
 02 November 2017 
Rural residence and risk of IBD
 02 November 2017 
Sexual functioning in Hep C
 01 November 2017 
Autoimmune pancreatitis in children
 01 November 2017 
Heartburn relief in adolescents with GERD
 31 October 2017 
Follow-up of positive results on fecal blood tests
 31 October 2017 
Surveillance in ulcerative colitis and Crohn’s disease
 30 October 2017 
Local recurrence after curative rectal cancer surgery
 30 October 2017 
Low-flow ascites pump in refractory cirrhosis
 30 October 2017 
Medical therapy of patients with pediatric-onset IBD
 27 October 2017 
NAFLD in advanced fibrosis in the USA
 27 October 2017 
Early readmission in cirrhosis after bacterial infections
 26 October 2017 
Predicting response to anti-TNF therapy in Crohn's

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2017 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us