Oxidative stress has been implicated in the pathophysiology of chronic pancreatitis.
Dr Payal Bhardwaj and colleagues from India evaluated the effects of antioxidant supplementation on pain relief, oxidative stress, and antioxidant status in patients with chronic pancreatitis.
The team randomized in a placebo-controlled double blind trial, consecutive patients with chronic pancreatitis to groups that were given placebo or antioxidants for 6 months.
The primary outcome measure was pain relief.
Secondary outcome measures were analgesic requirements, hospitalization, and markers of oxidative stress, and antioxidant status.
The researchers reported that 56 patients were assigned to the placebo or 71 to antioxidant groups.
|32% became pain free in the antioxidant groups|
After 6 months, the reduction in the number of painful days per month was significantly higher in the antioxidant group compared with the placebo group.
The team found the reduction in the number of analgesic tablets per month was also higher in the antioxidant group.
Furthermore, 32% and 13% of patients became pain free in the antioxidant and placebo groups, respectively.
The reduction in the level of thiobarbituric acid-reactive substances and increase in ferric-reducing ability of plasma were higher in the antioxidant group compared with the placebo group.
Dr Bhardwaj’s team concluded, “Antioxidant supplementation was effective in relieving pain and reducing levels of oxidative stress in patients with chronic pancreatitis.”