There is no consensus of opinion about postoperative adjuvant chemotherapy after radical surgery for advanced gastric cancer.
Dr Sun and colleagues performed a meta-analysis of the published results of relevant randomized clinical trials.
The team searched electronic databases from 1998 to 2007, and 12 randomized clinical trials were selected.
These included a total of 3809 patients.
The hazard ratio for overall survival was calculated.
The researchers found that the pooled hazard ratio for overall survival was 0.8 in favor of chemotherapy.
|The pooled hazard ratio for survival was 0.8 in favor of chemotherapy|
|British Journal of Surgery |
Subgroup analysis showed that the advantage of chemotherapy was not influenced by depth of tumor infiltration, status of lymph node metastasis, type of lymphadenectomy, geographical distribution of patients or route of drug administration.
Dr Sun’s team concluded, “Postoperative chemotherapy can improve overall survival after radical surgery for gastric cancer; there is no standardized chemotherapy regimen.”
“Japanese-style D2 radical surgery plus oral 5-fluorouracil appears an effective treatment at present.”