Few epidemiologic investigations characterize inflammatory bowel disease (IBD) in non-Caucasian children.
Dr Jolanda White and colleagues from the USA compared inflammatory bowel disease characteristics between African Americans and non–African Americans enrolled in a multicenter pediatric inflammatory bowel disease registry with endoscopic- and pathology-based diagnosis.
The team retrieved data entered from 2000 to 2003 on children 1 to 17 years old, inclusive, followed by a consortium of academic and community US pediatric gastroenterology practices.
The research team examined racial/ethnic differences by comparing the proportions of African Americans and non–African Americans in the following categories.
The team evaluated each diagnostic disease classification, age group at diagnosis or symptom onset, and presence of extraintestinal manifestations.
|African Americans more often had Crohn's disease at diagnosis|
|Clinical Gastroenterology & Hepatology |
In addition, the team noted that Z-scores for height and weight, immunomodulatory therapy, anatomic disease location, and abnormal hemoglobin, albumin, or sedimentation rate at diagnosis.
The researchers identified a total of 1406 patients with complete data, of which 10% were African American.
African Americans more often were older than 12 years of age at diagnosis and symptom onset, and had Crohn's disease more often.
The research team noted that African Americans had a low hemoglobin level at diagnosis.
Dr White’s team concluded, “Inflammatory bowel disease in African American children and adolescents presents more commonly with Crohn's disease and at older ages compared with non–African Americans.”
“Racial/ethnic differences in the epidemiology of inflammatory bowel disease, particularly Crohn's disease, among American youths require further investigation.”