Weight loss in overweight or obese individuals results in marked improvement or resolution of hypertension, diabetes mellitus, and hyperlipidemia.
However, the overall effect of weight loss on nonalcoholic fatty liver disease (NAFLD) remains unclear.
Dr Rajasekhara Mummadi and colleagues from Texas, USA systematically reviewed and conducted a meta-analysis in an effort to explore the effect of weight loss after bariatric surgical procedures on nonalcoholic fatty liver disease.
The researchers performed an electronic literature search of published articles on bariatric surgery and liver histology since inception in 2007.
Primary outcome measures were improvement and/or resolution in the 3 components of nonalcoholic fatty liver disease after bariatric surgery–induced weight loss.
|Pooled proportion of patients with steatohepatitis was 81%|
|Clinical Gastroenterology & Hepatology|
A pooled proportion of patients with improvement or resolution was calculated for steatosis, steatohepatitis, and fibrosis using a random effects model.
The researchers identified a total of 15 studies for final data extraction.
The percentage reduction in mean body mass index after bariatric surgeries ranged from 19 to 42.
The pooled proportion of patients with improvement or resolution in steatosis was 92%.
The pooled proportion of patients with steatohepatitis was 81%, in fibrosis was 66%, and for complete resolution of nonalcoholic steatohepatitis was 70%.
Dr Mummadi’s team concluded, “Steatosis, steatohepatitis, and fibrosis appear to improve or completely resolve in the majority of patients after bariatric surgery–induced weight loss.”