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 24 February 2018

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News

Prevalence of extraintestinal manifestations of Crohn's disease

A study in this month’s publication of Inflammatory Bowel Diseases investigates the prevalence of penetrating disease and extraintestinal manifestations of Crohn's disease detected with CT enterography.

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Dr David Bruining and colleagues from Minnesota, USA determined the prevalence of penetrating disease and extraintestinal manifestations of Crohn's disease identified by computed tomography (CT) enterography.

The research team examined the percentage of clinically significant new non-inflammatory bowel disease-related findings in these patients.

The team analyzed the records of 357 consecutive patients with previously diagnosed Crohn's disease who underwent a computed tomography enterography between 2004 and 2005.

21% had penetrating disease
Inflammatory Bowel Diseases

Radiology reports were reviewed for the presence of penetrating disease or extraintestinal inflammatory bowel disease manifestations.

Additional non-inflammatory bowel disease-related abnormalities were also recorded, including any mass or cystic lesion.

Urgent findings were defined as those that were deemed by the radiologist or ordering physician to require medical follow-up within 3 months.

The researchers found that of 357 patients identified, the median age was 42 years, and median disease duration was 10 years.

Of this cohort, 21% had penetrating disease, and 19% had extraintestinal inflammatory bowel disease manifestations.

The team noted that 6 patients had primary sclerosing cholangitis and portal/mesenteric vein thrombosis.

In addition, 45% had non-inflammatory bowel disease findings including 2 unsuspected malignancies.

Most of these extraenteric non-inflammatory bowel disease abnormalities were benign, with only 13% requiring urgent follow-up.

Dr Bruining’s team concluded, “CT enterography is a valuable diagnostic modality for detecting both penetrating disease and extraintestinal inflammatory bowel disease manifestations.”

“These data add to a growing body of evidence that supports the use of computed tomography enterography in Crohn's disease diagnostic and management algorithms.” 

Inflamm Bowel Dis 2008: 14(12): 1701-6


04 December 2008

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