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 24 November 2017

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News

H pylori eradication in long-term PPI users is cost-effective

H pylori eradication in long-term PPI users is highly cost-effective, finds the latest issue of Alimentary Pharmacology & Therapeutics.

News image

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Dr Mason and colleagues from the United Kingdom established if H pylori eradication in long-term proton pump inhibitors (PPI) users is cost-effective.

The team assigned 183 long-term PPI-using patients testing positive for H pylori to true or placebo eradication therapy.

Patients provided 2-year resource data, and 1-year symptom severity scores.

A within-trial cost effectiveness analysis was conducted from a British health service perspective.

Upper gastrointestinal endoscopies fell by 15%
Alimentary Pharmacology & Therapeutics

The researchers found significant reductions in resource use on comparing eradication with placebo.

After 2 years, PPI prescriptions fell by 3%, and clinician general practice consultations by 2%.

The team noted that upper gastrointestinal endoscopies fell by 15%, clinician gastrointestinal-related home visits by 20%, and abdominal ultrasound scans fell by 20%.

The team found that average net savings per patient were £93 after costs of detection, and eradication had been deducted.

At 1 year, Leeds Dyspepsia Questionnaire symptoms fell by 3, and quality-of-life measures improved favoring eradication.

Dr Mason’s team concluded, “H pylori eradication in infected, long-term PPI users is an economically dominant strategy, significantly reducing overall healthcare costs and symptom severity.”

Aliment Pharmacol Ther 2008: 28(11-12):


07 November 2008

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