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 20 November 2017

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News

Pegylated interferon and ribavirin improves graft survival in liver transplants

Impact of pegylated interferon and ribavirin treatment on graft survival in liver transplant patients with recurrent Hepatitis C, finds the latest issue of the American Journal of Transplantation.

News image

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Recurrent Hepatitis C virus infection is a major cause of morbidity and mortality after liver transplantation for Hepatitis C virus-related end stage liver disease.

Although previous studies have shown a short-term effect of interferon-based treatment on fibrosis progression, it is unclear whether this translates to improved graft survival.

Dr Veldt and colleagues from the Netherlands evaluated whether treatment of recurrent Hepatitis C virus leads to an improved graft survival.

The cohort study included consecutive Hepatitis C virus patients who underwent liver transplantation between 1995 and 2005 in the Mayo Clinic, Rochester.

The research team involved 215 patients in the study.

During a median follow-up of 4 years, 77% of patients had biopsy-proven recurrent Hepatitis C virus infection confirmed by serum Hepatitis C virus RNA testing.

77% had biopsy-proven recurrent Hepatitis C
American Journal Transplantation

There were no differences in MELD-score, fibrosis stage or time towards Hepatitis C virus recurrence between treated and untreated patients at time of recurrence.

There was a trend for greater frequency of acute cellular rejection among untreated patients.

The incidence of graft failure was lower for patients treated within 6 months of recurrence compared to patients not treated within this time-period.

Time-dependent multivariate Cox regression analysis showed that treatment of recurrent Hepatitis C virus infection was significantly associated with a decreased risk of overall graft failure.

The research team found a decreased risk of graft failure due to recurrent Hepatitis C virus.

Dr Veldt’s team concluded, “Although a cause and effect relationship cannot be established, treatment of recurrent Hepatitis C virus infection after liver transplantation is associated with a reduced risk of graft failure.”

Am J Transplant 2008: 8(11): 2426-33


16 October 2008

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