Despite the realization that health-related quality of life is an important outcome in patients with liver disease.
There is scarcity of disease-targeted health-related quality of life measures that have undergone prospective evaluation.
Dr Kanwal and colleagues from Israel prospectively validated the short form of liver disease quality of life instrument in patients with advanced liver disease.
The team found the short form of liver disease quality of life includes 36 disease-targeted items representing 9 domains.
|The internal consistency reliability coefficients were 0.70|
|Alimentary Pharmacology & Therapeutics|
The 9 domains included symptoms of liver disease, effects of liver disease, memory/concentration, sleep, hopelessness, distress, loneliness, stigma of liver disease and sexual problems.
The team administered the short form of liver disease quality of life to 156 advanced liver disease patients at baseline and at 6-month follow-up.
The team estimated internal consistency reliability for multi-item scales, and item discrimination across scale.
The research team constructed validity by estimating the associations of short form of liver disease quality of life scores with Short Form-36 scores, symptom severity and disability days.
The team evaluated the short form of liver disease quality of life’s responsiveness.
The researchers also assessed health-related quality of life changes for patients who received with those who did not receive liver transplantation.
The internal consistency reliability coefficients were 0.70 for 7 of 9 scales in baseline and for all scales in follow-up administration.
The short form of liver disease quality of life correlated highly with Short Form-36 scores, symptom severity, disability days and global health.
Patients undergoing liver transplantation reported improved health-related quality of life compared with patients without liver transplantation, and the responsiveness indices were excellent.
Dr Kanwal’s team concluded, “This study provides support for the reliability and validity of the short form of liver disease quality of life in patients with advanced chronic liver disease.”
“This instrument may be useful in everyday clinical practice and in future clinical trials.”