Dr Hemant Roy and colleagues from Washington, USA previously used novel biomedical optics technology, 4-dimensional elastically scattered light fingerprinting in experimental colon carcinogenesis.
The team showed that the predysplastic epithelial microvascular blood content is increased markedly in experimental models.
The team of doctors assessed the potential clinical translatability of this putative field effect marker.
The team characterized the early increase in blood supply in human beings in vivo.
|Early increase in blood supply correlated with adenoma size|
The doctors developed a novel, endoscopically compatible, polarization-gated, spectroscopic probe that was capable of measuring oxygenated and deoxygenated hemoglobin specifically in the mucosal microcirculation through polarization gating.
Microvascular blood content was measured in 222 patients from the endoscopically normal cecum, midtransverse colon, and rectum.
If a polyp was present, readings were taken from the polyp tissue along with the normal mucosa 10-cm and 30-cm proximal and distal to the lesion.
Tissue phantom studies showed that the probe had outstanding accuracy for hemoglobin determination.
Augmentation of microvasculature blood content was most pronounced within the most superficial layer and dissipated in deeper layers.
The early increase in blood supply was detectable within 30 cm from the lesion and the magnitude mirrored adenoma proximity.
This occurred for both oxygenated hemoglobin and deoxygenated, with the effect size being slightly greater for deoxygenate.
The team of doctors observed that early increase in blood supply correlated with adenoma size and was not engendered by nonneoplastic polyps.
Dr Roy’s team concluded, “In vivo microvascular blood content can be measured and provides an accurate marker of field carcinogenesis.”
“This technological/biological advance has numerous potential applications in colorectal cancer screening such as improved polyp detection and risk stratification.”