Epidemiological reports on risk and prognostic factors in patients with mesenteric venous thrombosis are scarce.
Dr Acosta and colleagues from the United Kingdom identified patients with mesenteric venous thrombosis through the inpatient and autopsy registry between 2000 and 2006 at Malmö University Hospital in Sweden.
|D-dimer at admission was raised in all 5 patients tested|
|British Journal of Surgery|
The team found that 51 patients had mesenteric venous thrombosis, and 6 were diagnosed at autopsy.
The highest incidence of 11 per 100, 000 person-years was in the age category 70 to 79 years.
The research team noted that activated protein C resistance was present in 13 of 29 patients tested.
D-dimer at admission was raised in all 5 patients tested.
Multidetector row computed tomography in the portal venous phase was diagnostic in all 20 patients investigated, of whom 19 were managed conservatively.
The researchers found that the median length of resected bowel in 12 patients who had surgery was 0.6 m.
The overall 30-day mortality rate was 20%.
The team observed that intestinal infarction, treatment on a non-surgical ward, and computed tomography not done were associated with increased mortality.
Cancer was independently associated with long-term mortality.
Portal venous phase computed tomography appeared sensitive in diagnosing mesenteric venous thrombosis.
Dr Acosta’s team concluded, “As activated protein C resistance was a strong risk factor, lifelong anticoagulation should be considered.”