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News

Spontaneous tumor perforation reduces survival after colon cancer surgery

The most recent issue of Colorectal Disease examines the impact of spontaneous tumor perforation on outcome following colon cancer surgery.

News image

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Dr Abdelrazeq and colleagues from the United Kingdom examined the impact of spontaneous tumor perforation on survival following surgery for colon cancer is unclear.

The team compared survival outcomes for patients with perforated colonic cancer with stage-matched nonperforated cancer.

The team searched a prospective histological database for all patients undergoing resection for adenocarcinoma of the colon between 1996 and 2002.

Overall survival at 5 years was 28% for perforated cancers
Colorectal Disease

Patients with T4 cancer were selected and classified into those with spontaneous perforation at the tumor site and those with nonperforated tumor.

Patients with synchronous colonic and rectal cancers, familial polyposis, inflammatory bowel disease, iatrogenic or remote colonic perforation were excluded.

The team combined histological variables were combined with clinical data obtained by case note review.

Data were analyzed for differences in demographics, histological variables, operative mortality, disease-free and overall survival.

Multivariate analysis of factors predictive of overall survival in both groups was performed.

The researchers identified 960 patients, 52 patients had spontaneous tumor perforation, and 82 patients served as the T-stage matched control group.

Overall survival at 2 years was 47% and 54%, and at 5 years was 28% and 33% for perforated and nonperforated cancers, respectively.

Patients with perforated cancers were more likely to present with metastatic disease and undergo emergency surgery with a higher 30-day mortality.

The team found a trend towards reduced overall survival in the perforated group, but no difference in disease-free survival.

On multivariate testing, 'emergency surgery' and 'age over 75 years' were the only independent predictors of mortality in the perforated and nonperforated group respectively.

Dr Abdelrazeq’s team concluded, “Both perforated and nonperforated T4 colon cancers have a poor prognosis.”

“Spontaneous perforation of the cancer is associated with reduced overall survival, due to higher 30-day mortality In itself does not appear to significantly impact on disease-free survival.”

“Rather, it is the advanced oncological stage at which perforated cancers present that determines outcome.” 

Col Dis 2008: 10(8): 775-80


25 September 2008

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