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 21 April 2018

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News

Hospital-acquired infection increased mortality in acute pancreatitis

A study in this month’s Gastroenterology examines the impact of hospital-acquired infection on outcome in acute pancreatitis.

News image

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Little is known regarding the impact of hospital-acquired infection in acute pancreatitis.

Dr Bechien and colleagues from Massachusetts, USA conducted a population-based assessment of the impact of hospital-acquired infection on outcome in acute pancreatitis.

Patient data were obtained from the Cardinal Health Clinical Outcomes Research Database, a large population-based data set.

Cases with principal diagnosis by International Classification of Diseases between 2004 and 2005 were identified.

These cases were linked with recently reported hospital-acquired infection data collected by the Pennsylvania Health Care Cost Containment Council.

Identification of hospital-acquired infection was based on definitions set forth by the National Nosocomial Infection Surveillance System.

The researchers conducted a 5:1 multivariate propensity-matched cohort study to determine the independent contribution of hospital-acquired infection to in-hospital mortality, length of stay, and hospital charges.

Overall mortality was 28% with hospital-acquired infection
Gastroenterology

From 177 participating hospitals, there were 11,046 acute pancreatitis cases identified.

The team noted that less than 1% of patients developed an hospital-acquired infection.

Mortality in the overall acute pancreatitis population was 1% vs 11% among 405 matched non-hospital-acquired infection controls.

Overall mortality was 28% among patients who developed hospital-acquired infection.

The research team found that 15% of all deaths was associated with an hospital-acquired infection.

Both average length of stay and hospital charges were significantly increased among patients with hospital-acquired infection compared with matched non-hospital-acquired infection controls.

Dr Bechien’s team commented, “We determined that hospital-acquired infection had a major impact on mortality in acute pancreatitis.”

“Patients who developed hospital-acquired infection also had significantly increased length of stay and hospital charges.”

“These differences were not explained by increased disease severity alone.”

“Reducing hospital-acquired infection is an important step to improving outcome in acute pancreatitis.”

 

Gastroenterology 2008: 135(3): 816-20


22 September 2008

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