Recent studies have demonstrated the relationship between Helicobacter pylori infection and the risk of colorectal carcinoma.
However, the results of these studies remain controversial as the studies were relatively small in size and partially differed in designs.
Dr Ya-shuang Zhao and colleagues from China reviewed the published studies and carried out a meta-analysis to further explore this relationship.
|The odds ratio for the association between H pylori and colorectal cancer was 1.5|
|International Journal of Colorectal Disease |
The team performed an extensive systematic review to find all the published case-control studies up to 2007 using electronic searching, hand searching, and reference lists of retrieved articles.
Odds ratio was employed to evaluate the relationship of H pylori infection and risk of colorectal cancer.
Summary estimates were obtained using random effect models according to the result of a statistical test for heterogeneity across the studies.
The presence of possible publication bias was assessed using different statistical approaches.
The researchers included 13 studies, and a summary odds ratio of 1.5 was estimated for the association between H pylori infection and colorectal cancer.
A summary odds ratio of 1.6 was estimated for the association between immunoglobulin G antibody and colorectal cancer risk.
The team observed that the graphical funnel plot appeared asymmetrical, but found no statistical evidence of publication bias.
The method of fail-safe suggested that the effect of publication bias was small.
Dr Zhao's team concluded, "Current evidence, though limited, suggests that there is a possible increase in risk of colorectal cancer because of H pylori infection."