The optimal clinical management of children hospitalized with ulcerative colitis is evolving.
There are limited data quantifying the number of pediatric patients with ulcerative colitis admitted to hospitals in the United States.
Dr Stephen Guthery and colleagues from Utah, USA analyzed the Kids' Inpatient Database (KID, 2003), to estimate the distribution of hospitalized children with ulcerative colitis and estimate sample sizes available for clinical research.
|9% underwent colectomy during their hospitalization|
The research team limited thier analysis to subjects aged less than 18 years.
The team defined cases of ulcerative colitis as discharge records associated with an ICD-9 code of 556.0-556.9 in the first position.
The team defined colectomy as principal procedure code of 45.8, and generated weighted estimates for these analyses.
The research team estimated the relationship between number of patients and number of hospitals necessary for clinical trials using 1000 simulated datasets.
The researchers identified a total of 2311 ulcerative colitis cases.
The mean age at admission was 13 years, and 9% underwent colectomy during their hospitalization.
The researchers found that 1008 ulcerative colitis cases were treated at high-volume hospitals, and that the majority were treated at children's hospitals.
Simulation studies suggest that 5 high-volume hospitals would be necessary to generate sample sizes necessary for a pilot clinical trial of refractory ulcerative colitis.
Dr Guthery and colleagues commented, "Approximately half of all young patients hospitalized with ulcerative colitis in the USA were treated at a limited number of high-volume hospitals."
"We found that 5 such centers would be adequate for pilot clinical trials of hospitalized patients with refractory ulcerative colitis."