Dr Ludvigsson and colleagues from Sweden examined the risk of subsequent sepsis in individuals with celiac disease.
The research team used Swedish national health registers to identify 15,325 individuals with a diagnosis of celiac disease, and 14,494 inpatient reference individuals.
|The hazard ratios for pneumococcal sepsis was 4|
Cox regression estimated the hazard ratios for subsequent sepsis.
The researchers found that, compared with inpatient reference individuals, individuals with celiac disease were at increased risk of sepsis.
The highest risk estimates were seen for pneumococcal sepsis.
Individuals with celiac disease diagnosed in childhood were not at increased risk of subsequent sepsis.
The team then compared those with celiac disease with reference individuals from the general population.
The research team noted that celiac disease was associated with an increased risk of sepsis.
The hazard ratios for pneumococcal sepsis was 4.
In this comparison, the team observed that children with celiac disease were also at an increased risk of sepsis.
Dr Ludvigsson's team concluded, "This study showed a modestly increased risk of sepsis in patients with celiac disease with the highest risk for pneumococcal sepsis."
"This risk increase was limited to those with celiac disease diagnosed in adulthood."
"Potential explanations include hyposplenism, increased mucosal permeability and an altered composition of the intestinal glycocalyx in individuals with celiac disease."