Liver transplantation provides long-term survival for adults with end-stage liver disease.
As a result of improved survival and an aging United States population the demand for liver transplantation in older patients is expected to increase.
Dr Nyingi Kemmer and colleagues from the USA described the transplantation trends in the older recipient above 65 years of age.
|The 10-year patient survival was 42% if over 65 years|
The research team used the United Network for Organ Sharing database, and identified liver transplantation recipients between 1990 and 2006.
The team used Kaplan-Meier method to calculate overall survival at 1, 3, 5 and 10 years, and Cox regression for predictors of survival.
The researchers found during the study period that 5,630 liver transplantation recipients were older than 65 years.
The team reported that 79% were whites, 10% were Hispanic, and 4% were African Americans.
There was an increase in liver transplantation for older patients from 4% in 1990 to 10% in 2006, and a regional variation.
The 10-year patient and graft survival was 60% and 57% for less than 65 years versus 42% and 40% for more than 65 years.
With age stratification, there was no difference in survival but when adjusted for race there was a significant difference in graft survival with a 10 year.
Dr Kemmer's team concluded, "The demand for liver transplantation in recipients older than 65 years is increasing."
"Although their survival is lower in comparison with recipients less than 65 years, there seems to be no difference in unadjusted survival with age stratification above 65 years."
"Among ethnic minorities, there was a disproportionately lower percentage of African Americans liver transplantation and a decreased survival."