Recent studies suggest that diabetes mellitus increases the risk of developing hepatocellular carcinoma.
Dr Bart Veldt and colleagues from the Netherlands quantified the risk of hepatocellular carcinoma among patients with both diabetes mellitus and Hepatitis C in a large cohort of patients with chronic Hepatitis C and advanced fibrosis.
|13% of patients with diabetes mellitus developed hepatocellular carcinoma|
The team assessed 541 patients of whom 85 had diabetes mellitus.
The median age at inclusion was 50 years.
The prevalence of diabetes mellitus was 11% for patients with Ishak fibrosis score 4, 13% for Ishak score 5, and 19% for Ishak score 6.
The team used multiple logistic regression analysis to show an increased risk of diabetes mellitus for patients with an elevated body mass index.
The research team noted a decreased risk of diabetes mellitus for patients with higher serum albumin levels.
The researchers found that during a median follow-up of 4 years, 13% of patients with diabetes mellitus versus 6% of patients without diabetes mellitus developed hepatocellular carcinoma.
The 5-year occurrence of hepatocellular carcinoma was 11% and 5%, respectively.
The team found that in patients with Ishak 6 cirrhosis, diabetes mellitus was independently associated with the development of hepatocellular carcinoma.
Dr Veldt's team concluded, "For patients with chronic Hepatitis C and advanced cirrhosis, diabetes mellitus increases the risk of developing hepatocellular carcinoma."