The presence of abnormal microcapillaries detected by narrow band imaging with magnifying colonoscopy has been reported to be a marker of colorectal neoplasia.
Dr Katagiri and colleagues from Japan prospectively investigated if narrow band imaging with magnification could help predict the histology of early colorectal neoplasia.
|Alimentary Pharmacology & Therapeutics|
The team studied a series of 104 consecutive patients with 139 colorectal lesions.
All lesions were detected by conventional colonoscopy and subsequently evaluated by narrow band imaging with magnification.
During narrow band imaging with magnification, the microvascular architecture observed on the surface of the detected lesions, capillary patterns, was categorized.
Non-neoplastic lesions were classified as capillary patterns 1, and neoplastic lesions as capillary patterns 2 and 3.
Only lesions endoscopically diagnosed as capillary patterns 2 or 3 were included in the study.
All of the lesions were resected endoscopically or surgically, and were examined histologically for comparison.
The researchers reported that 97% of colorectal neoplastic lesions with capillary patterns 2 were histologically diagnosed as low-grade dysplasia.
The research team noted that 87% of the colorectal neoplastic lesions with capillary patterns 3 were high-grade dysplasia or invasive cancer.
Dr Katagiri's team concluded, "Capillary patterns observed by narrow band imaging with magnification could be used to assess the degree of atypia in early colorectal neoplasia."