Radiofrequency ablation therapy for hepatocellular carcinoma has enabled good local control to be possible.
After successful local control, distant recurrences frequently occur in the remnant liver.
Dr Fuke and colleagues from Japan identified the predictive factors for distant recurrence after Radiofrequency ablation.
|Local recurrence rates were 2% at 5 years|
|Alimentary Pharmacology & Therapeutics|
The team selected a total of 117 patients with initial non-advanced hepatocellular carcinoma with Hepatitis C who underwent radiofrequency ablation after transcatheter chemoembolization.
Radiofrequency ablation was performed under real-time computed tomography-fluoroscopic guidance.
The team studied survival rates, local and distant recurrence rates, as well as predictive factors for distant recurrence.
The researchers found that after radiofrequency ablation, survival rates were 98% and 65% at 1 and 5 years, respectively.
Child B patients had a significantly worse survival than Child A.
Recurrence rates were 2% at 5 years for local, and 17% and 77% at 1 and 5 years, respectively, for distant.
The research team observed significantly high recurrence rates in cases with low albumin levels, and high aspartate aminotransferase levels.
High alanine aminotransferase levels, low platelet counts and high alpha-fetoprotein levels gave high recurrence rates.
The team found that low albumin levels and high aspartate aminotransferase levels were independent predictive factors for distant recurrence.
Dr Fuke's team concluded, "Although Radiofrequency ablation enables good local control for initial hepatocellular carcinoma, distant recurrence is observed at high rates in Hepatitis C patients."
"Low albumin and high aspartate aminotransferase levels are predictive factors for distant recurrence."