Dr Michael Goldacre and colleagues from the United Kingdom determined the risk of cancer in cohorts of patients with alcoholic cirrhosis.
The patients also had other alcoholic liver diseases, other and unspecified cirrhosis, primary biliary cirrhosis, viral hepatitis, acute and chronic pancreatitis.
|Oral cavity cancers were elevated in the alcoholic cirrhosis cohort|
|European Journal of Gastroenterology & Hepatology|
The research team analyzed linked hospital and mortality data in an area in southern England using a statistical database.
The researchers noted that compared with the control cohort, rate ratios for cancer overall were elevated.
Rate ratios for cancer were particularly high for liver cancer in patients with alcoholic cirrhosis, with other and unspecified cirrhosis, and with other alcoholic liver diseases.
Rate ratios for cancer were also raised for primary biliary cirrhosis, and with viral hepatitis.
The team found that pancreatic cancer risk was significantly and substantially elevated in all cohorts except that with primary biliary cirrhosis.
Lung cancer risk was significantly high in all cohorts except those with primary biliary cirrhosis and viral hepatitis.
The team observed that oral cavity cancers were elevated in the alcoholic cirrhosis cohort, and the other alcoholic liver diseases cohort, as was colon cancer.
The research team noted that non-Hodgkin's lymphoma was significantly elevated in the group of 'other and unspecified cirrhosis'.
Dr Goldacre‘s team concluded, "All 7 conditions carry an increased risk of cancer, but each condition has a somewhat different profile of cancer risk associated with it."