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 25 November 2017

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News

Racial differences in liver transplant outcomes in the MELD era

This month's American Journal of Gastroenterology finds racial differences in liver transplantation outcomes in the MELD era.

News image

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The Model for End-Stage Liver Disease score was introduced to better allocate donor livers in 2002.

Racial differences in orthotopic liver transplantation outcomes prior to this time have been attributed to late listing of some racial groups.

Hispanics had better overall, and graft survival
American Journal of Gastroenterology

The team found that racial differences in post-transplant survival in the Model for End-Stage Liver Disease era have not been previously examined.

Drs Kia Saeian and Ashwin Ananthakrishnan from Wisconsin, USA performed a retrospective observational cohort study using the United Network for Organ Sharing database for adult liver transplants performed between 2002 and 2006.

The team examined patient, and graft survival at 2 years, and compared disease-specific survival rates among the different races.

The researchers included a total of 10,409 whites, 1,133 blacks, 1,548 Hispanics, and 765 transplant recipients belonging to other races in the study.

On multivariate analysis, blacks had lower overall, and graft survival at 2 years compared to whites, while Hispanics had better overall, and graft survival.

The researchers found that, compared to whites, blacks transplanted for Hepatitis C or hepatocellular carcinoma had lower survival at 2 years.

Dr Saeian's team concluded, "In the Model for End-Stage Liver Disease era, black patients have significantly lower overall, and graft survival at 2 years compared to whites."

Am J Gastroenterol 2008: 103(4): 901-10
14 April 2008

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