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 27 May 2018

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News

Factors predicting survival in advanced esophageal cancer

March's issue of the Alimentary Pharmacology & Therapeutics identifies factors predicting survival in advanced esophageal cancer.

News image

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Esophageal cancer is often diagnosed at an advanced stage, with poor prognosis and severe morbidity.

In the majority of cases, palliative treatment is the only option available.

Dr Bergquist and colleagues from Sweden identified factors that can predict survival for patients with incurable cancer of the esophagus or gastro-esophageal junction and hence aid in the choice of treatment.

3 of the health-related quality of life questionnaire scales added prognostic information
Alimentary Pharmacology & Therapeutics

The team identified 96 patients and applied health-related quality of life questionnaires.

The research team performed computerized tomography-derived size assessment of the primary tumors.

The team used univariate and multivariate Cox-regression analyses to determine potential predictors of survival.

The researchers found that Karnofsky Index, occurrence of metastases, and Union International Contre le Cancer-stage were related to survival.

Computerized tomography-derived tumor size assessment and 10 of 25 scales, and single items from the health-related quality of life questionnaires were related to survival.

The team observed that 3 of the health-related quality of life questionnaire scales added prognostic information to M-stage, the single strongest predictor.

These 3 scales included physical functioning, fatigue and reflux.

Dr Bergquist's team concluded, "In addition to M-stage, the outcome of health-related quality of life questionnaires can sharpen the prediction of survival in patients with advanced cancer of the oesophagus, and gastro-esophageal junction."

"This will aid in the choice of palliative treatment strategy."

Aliment Pharmacol Ther 2008: 27(5): 385-95
08 February 2008

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