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 18 January 2018

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News

Factors that influence IBD response in pediatric patients

Researchers in this month's issue of the Journal of Pediatric Gastroenterology & Nutrition measure quality of life and disease response in pediatric patients with IBD.

News image

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Dr James Perrin and colleagues developed a pediatric inflammatory bowel disease (IBD) health-related quality of life measure.

The research team determined factors associated with generic health-related quality of life measures and clinical variables.

Social functioning is a reliable factor for IBD responses
Journal of Pediatric Gastroenterology & Nutrition

The team evaluated a cross-sectional survey of children and adolescents ages 8 years to 18 years, and their parents attending any of 6 US inflammatory bowel disease centers.

The children were recruited from either existing registry of age-eligible subjects or visits to participating centers.

The survey included generic and inflammatory bowel disease-specific quality of life measures, disease activity, and other clinical indicators.

The team carried out factor analysis of impact responses, comparing resulting factors with results on the generic health-related quality of life and the clinical measures.

The researchers included 220 subjects, of which 161 had Crohn's disease, and 59 had ulcerative colitis.

Initial confirmatory factor analysis did not support the 6 proposed Impact domains.

Exploratory factor analysis indicated 4 factors with good to excellent reliability for inflammatory bowel disease responses.

These included general well-being and symptoms, emotional functioning, social interactions, and body image.

The team found that 2 items did not load well on any factor.

The 4 factors correlated well with the Pediatric Quality of Life Inventory and subscales.

Children with higher disease activity scores and other indicators of clinical activity reported lower health-related quality of life.

Dr Perrin‘s team concluded, "This study provides further characteristics of a health-related quality of life measure specific to pediatric inflammatory bowel disease."

"It indicates ways to score the measure based on the resulting factor structure."

"The measure correlates appropriately with generic health-related quality of life measures and clinical severity indicators."

J Ped Gastroenterol Nutr 2008: 46(2): 164-71
06 February 2008

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