There are unresolved issues regarding the security of liver transplantation with non-heart-beating donors.
Recently, an increased incidence of biliary complications, mainly intrahepatic ischemic-type biliary strictures, has been described after controlled non-heart-beating donors.
|42% in the non-heart-beating donors group suffered any type of biliary complication|
Dr Francisco Suarez and colleagues studied the incidence, and risk factors for biliary complications among uncontrolled non-heart-beating donors recipients compared with a large population of heart-beating donor recipients.
The researchers found that overall, 17% of patients in the heart-beating donor group suffered any type of biliary complication.
The researchers found that 42% of patients in the non-heart-beating donors group suffered any type of biliary complication.
The team assessed that the incidence of nonanastomotic biliary strictures was significantly greater in the non-heart-beating donors group.
Multivariate analysis showed that independent risk factors for nonanastomotic strictures were hepatic artery thrombosis, and receiving a liver from a non-heart-beating donor.
Dr Suarez' team concluded, "If this type of donors is accepted as a source of liver organs, the high incidence of biliary complications should be considered, and efforts should be made to decrease ischemic injury."