Dr Stephen Alexander and colleagues from Australia investigated
an allograft transplanted from a deceased male donor into a 9-year-old girl.
The team of doctors observed complete hematopoietic chimerism and tolerance of the liver allograft.
The doctors found no evidence of graft-versus-host disease 17 months after transplantation.
|The tolerance was preceded by a period of severe hemolysis|
|The New England Journal of Medicine|
The tolerance was preceded by a period of severe hemolysis, reflecting partial chimerism that was refractory to standard therapies.
Dr Alexander's team concluded," The hemolysis resolved after the gradual withdrawal of all immunosuppressive therapy."