Patients with Barrett's esophagus are at increased risk of esophageal adenocarcinoma.
Observational studies have suggested increase in overall mortality also but data are conflicting.
Professor Moayyedi and colleagues from Canada assessed the cause of death in patients with Barrett's esophagus compared with the general population.
|The main disease area responsible includes esophageal adenocarcinoma|
|Alimentary Pharmacology & Therapeutics|
The research team retrospectively evaluated patients with Barrett's esophagus in 4 hospitals in the United Kingdom using electronic endoscopy and histopathology records from 1997 to 2003.
Data on deaths from this cohort of patients were identified through the Office of National Statistics and compared with age- and gender-adjusted mortality in the Leicestershire region.
The researchers identified 1272 Barrett's patients with 245 deaths in this cohort.
The team of researchers found that mortality increased.
The main disease area that was responsible for this increase included esophageal adenocarcinoma.
Bronchopneumonia, and ischemic heart disease also contributed the increase in mortality.
Professor Moayyedis' team concluded, "Patients with Barrett's esophagus die more commonly of bronchopneumonia, and ischaemic heart disease compared with esophageal adenocarcinoma, and overall mortality in this group may be increased."