Help
Subscribe


GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy

 21 November 2017

Advanced search
GastroHep.com - the global online resource for all aspects of gastroenterology, hepatology and endoscopy Profile of Roy Pounder

Home

News  
Journals
Review Articles
Slide Atlas
Video Clips
Online Books
Advanced Digestive Endoscopy
Classical Cases
Conference Diary
PubMed
International GH Links
USA GH Links
National GH Links
National GI Societies
Other Useful Links




Emails on Gastroenterology and Hepatology
the National AIDS Treatment Advocacy Project
Visit the gastroenterology section of the EUMS

News

Good long-term outcomes with seroconversion in chronic Hep B

This month's Gut investigates long-term outcome of chronic Hepatitis B in patients after 25 years.

News image

fiogf49gjkf04

Dr Fattovich and colleagues from Italy assessed risk factors for liver-related death.

The team re-evaluated, after a median follow-up of 25 years, a cohort of 70 Caucasian patients with Hepatitis B e antigen positive chronic hepatitis at presentation.

Follow-up studies included clinical and ultrasound examinations, biochemical and virological tests, and cause of death.

25-year survival probability was 50% with Hep B e antigen negative hepatitis
Gut

The researchers assessed 61 patients who underwent spontaneous Hepatitis B e antigen seroconversion.

The team found that during a median period of 23 years after Hepatitis B e antigen seroclearance, 66% of patients became inactive carriers.

The team observed that the remaining 34% showed alanine aminotransferase elevation.

Of these, 1% had Hepatitis B e antigen reversion, and 15% had detectable serum Hepatitis B virus DNA but were negative for Hepatitis B e antigen.

A further 13% had concurrent virus infection, and 5% had concurrent non-alcoholic fatty liver disease.

The researchers noted that liver-related death occurred in 16% of patients, caused by hepatocellular carcinoma in 5 patients and liver failure in 6 patients.

The 25-year survival probability was 40% in patients persistently Hepatitis B e antigen positive.

The team observed that the 25-year survival probability was 50% in patients with Hepatitis B e antigen negative chronic Hepatitis or reversion, and 95% in inactive carriers.

The team found that older age, male sex, cirrhosis at entry and absence of sustained remission predicted liver-related death independently.

The adjusted hazard ratio for liver related death was 33 for persistently Hepatitis B e antigen positive patients.

The team noted that the adjusted hazard ratio for liver related death was 39 for those with Hepatitis B e antigen negative chronic Hepatitis or reversion relative to inactive carriers.

Dr Fattovich's team concluded, "Most patients with Hepatitis B e antigen seroconversion became inactive carriers with very good prognosis."

"The risk of liver-related mortality in Caucasian adults with chronic Hepatitis is strongly related with sustained disease activity and ongoing high level of Hepatitis B virus replication independently of Hepatitis B e antigen status."

Gut 2008: 57(1): 84-90
03 January 2008

Go to top of page Email this page Email this page to a colleague

 21 November 2017 
Prepregnancy obesity and maternal mortality
 21 November 2017 
Preoperative optimization in IBD patients
 21 November 2017 
Cholangiopathy in critically ill patients
 20 November 2017 
Barriers to hepatitis C treatment
 20 November 2017 
Socioeconomic characteristics in diverticular disease
 20 November 2017 
Endoscopic indices of disease activity for Crohn’s
 17 November 2017 
Food elimination diets for treatment of adults with eosinophilic esophagitis
 17 November 2017 
PPI use and cognitive function in women
 17 November 2017 
Predicting microscopic colitis
 16 November 2017 
NAFLD-hepatocellular carcinoma and survival after orthotopic liver transplant
 16 November 2017 
Prepregnancy obesity and severe maternal morbidity
 16 November 2017 
Celiac disease screening in adult first-degree relatives
 15 November 2017 
Breastfeeding and the risk of IBD
 15 November 2017 
Medication nonadherence and health care costs
 15 November 2017 
Predicting recurrence after curative rectal cancer surgery
 14 November 2017 
HBV/HCV coinfection and cirrhosis
 14 November 2017 
Sexual dysfunction after rectal cancer surgery
 14 November 2017 
Eosinophilic gastroenteritis and colitis
 13 November 2017 
GI bleeding in patients taking non–vitamin K antagonist oral anticoagulants
 13 November 2017 
Genetic polymorphisms, fatty acids and ulcerative colitis
 13 November 2017 
Flares after immunomodulator withdrawal in Crohn's
 10 November 2017 
Thiopurines vs TNF and lymphoma risk in IBD
 10 November 2017 
Drug monitoring of anti-tumour necrosis factor therapy in IBD
 10 November 2017 
Treatment decisions for older patients with colorectal cancer
 09 November 2017 
Quality standards in upper gastrointestinal endoscopy
 09 November 2017 
Irradiated rectal cancer and chemoradiotherapy
 09 November 2017 
Environmental factors and IBD
 08 November 2017 
Prophylaxis of spontaneous bacterial peritonitis
 08 November 2017 
Optimal management of postoperative Crohn's disease
 07 November 2017 
Community Screening for Helicobacter pylori
 07 November 2017 
Early readmission in IBD patients
 07 November 2017 
Mesocolic excision for colon cancer
 06 November 2017 
Food elimination diet for children with eosinophilic esophagitis
 06 November 2017 
Biologic agents and obesity in children with IBD
 06 November 2017 
Liver cancer burden despite extensive use of antiviral agents
 03 November 2017 
Statins and mortality in chronic viral hepatitis
 03 November 2017 
Propofol for outpatient colonoscopy
 03 November 2017 
Asthma and IBD development
 02 November 2017 
Diverticulitis and emergency department burden
 02 November 2017 
Sexual functioning in Hep C
 02 November 2017 
Rural residence and risk of IBD
 01 November 2017 
Heartburn relief in adolescents with GERD
 01 November 2017 
Autoimmune pancreatitis in children
 31 October 2017 
Follow-up of positive results on fecal blood tests
 31 October 2017 
Surveillance in ulcerative colitis and Crohn’s disease
 30 October 2017 
Local recurrence after curative rectal cancer surgery
 30 October 2017 
Low-flow ascites pump in refractory cirrhosis
 30 October 2017 
Medical therapy of patients with pediatric-onset IBD
 27 October 2017 
NAFLD in advanced fibrosis in the USA
 27 October 2017 
Early readmission in cirrhosis after bacterial infections
 26 October 2017 
Predicting response to anti-TNF therapy in Crohn's
 26 October 2017 
Conversion to open laparotomy in rectal cancer
 25 October 2017 
Conversion of colonoscopy to sigmoidoscopy
 25 October 2017 
Fecal microbiota transplantation
 25 October 2017 
Rifaximin and survival in hepatic encephalopathy
 24 October 2017 
Eosinophilic esophagitis with swallowed topical corticosteroids
 24 October 2017 
Meta-analysis in nutritiona research
 23 October 2017 
NAFLD-related hepatocellular carcinoma in liver resection
 23 October 2017 
Outcome of hepatic sarcoidosis
 20 October 2017 
Conversion of planned colonoscopy to sigmoidoscopy

Blackwell Publishing


GastroHep.com is a Blackwell Publishing registered trademark
© 2017 Wiley-Blackwell and GastroHep.com and contributors
Privacy Statement
Disclaimer
About Us