Autoimmune hepatitis predominantly affects women.
Reasons for this are unclear and few series have assessed long-term outcomes of men with autoimmune hepatitis.
Dr Michael Heneghan and colleagues evaluated the clinical course and outcomes of 51 men from a total of 238 consecutive patients with definite autoimmune hepatitis at a single center from 1971 to 2005.
|About 71% of men experienced at least 1 relapse|
|Journal of Hepatology|
The team's primary outcome measure was death or liver transplantation.
The researchers reported that median age at diagnosis was 39 years in men and 49 years in women.
The researchers found that the HLA A1, B8 and DR3 allotypes and the HLA A1-B8-DR3 haplotype were more frequently expressed in men.
The team noted that there were no significant differences in clinical manifestations at presentation.
Over 96% of patients demonstrated a complete initial response to treatment.
About 71% of men experienced at least 1 relapse vs 55% of women.
However, women were significantly more likely to die or require liver transplantation.
Dr Al-Chalabi's concludes, "Men with autoimmune hepatitis appear to have a higher relapse rate and younger age of disease onset which may relate to increased prevalence of HLA A1-B8-DR3."
"Despite this, men have significantly better long-term survival and outcomes than women."