Metabolic syndrome is associated with severe fibrosis in chronic viral hepatitis and non-alcoholic steatohepatitis.
The prevalence of metabolic syndrome and its possible impact on the severity of liver histological lesions have not been studied prospectively in chronic liver diseases.
Dr Papatheodoridis and colleagues from Greece investigated the prevalence of metabolic syndrome in patients with chronic viral hepatitis or non-alcoholic steatohepatitis.
The researchers determined its associations with histological severity.
|The metabolic syndrome occured in 41% with non-alcoholic steatohepatitis|
|Alimentary Pharmacology & Therapeutics|
The team prospectively evaluated 317 patients.
Of these, 95 had Hepatitis B e antigen-negative chronic Hepatitis B, 176 had chronic Hepatitis C, and 46 had non-alcoholic steatohepatitis with liver biopsy.
Metabolic syndrome was defined using the Adult Treatment Panel III criteria.
Histological lesions were evaluated according to Ishak's or Brunt's classification.
The team found the metabolic syndrome was present in 10% of patients.
The metabolic syndrome occured in 41% of patients with non-alcoholic steatohepatitis, and in 5% with chronic viral hepatitis.
The team found that in chronic viral hepatitis, cirrhosis was independently associated with increasing age.
Chronic viral hepatitis was also associated with higher aspartate aminotransferase, and gamma-glutamyl-transpeptidase levels.
The team noted that severe necroinflammation, and the metabolic syndrome were both associated with chronic viral hepatitis.
In non-alcoholic steatohepatitis, severe fibrosis was independently associated with severe necroinflammation and metabolic syndrome.
Presence of metabolic syndrome was not associated with presence or severity of steatosis both in chronic viral hepatitis, and in non-alcoholic steatohepatitis.Dr Papatheodoridis' team concluded, "Metabolic syndrome is more prevalent in non-alcoholic steatohepatitis than in chronic viral hepatitis."
"It is associated independently with more severe fibrosis but not with the severity of steatosis, both in chronic viral hepatitis and in non-alcoholic steatohepatitis."