Gastric juice is usually discarded during upper-gastrointestinal l(GI) endoscopy.
By using a novel device, the Mt 21-42, Dr Antonio Tucci and from Italy evaluated the potential of this important organic fluid in clinical practice.
The team explored its contribution to the diagnosis of Helicobacter pylori infection and atrophic gastritis of the oxyntic mucosa.
|Gastric-juice analysis allowed detection of H pylori in 98% of cases|
The team assessed a multicenter study of 17,907 patients in 10 endoscopy units.
The research team estimated the frequency of diagnosis of atrophic gastritis of the oxyntic mucosa and H pylori infection in routine endoscopic practice.
A prospective study of 216 patients at 1 of these units aimed to determine the real prevalence of these conditions, and the possible benefits of gastric juice analysis.
The team considered gastric juice pH and ammonium concentration, as well as endoscopic and histologic features.
The team also measured serologic parameters for atrophy and H pylori, gastric acid secretion, and costs.
The researchers found that H pylori infection and atrophic gastritis of the oxyntic mucosa were greatly underdiagnosed in routine endoscopic practice.
The team reported that this was because of the intrinsic limitations of the conventional tests and lack or inappropriateness of biopsy planning.
Gastric-juice analysis proved to be a cheap, simple, and effective way to prevent such under diagnosis.
In addition, gastric-juice analysis allowed detection of atrophic gastritis and H pylori in 96% and 98% of cases, and saved costs.
Dr Tucci's team concluded, "Gastric juice provided a valuable source of clinicopathologic information."
"Properly analyzed, it allowed detection of the main risk factors for gastric cancer."
"Gastric juice analysis overcomes the diagnostic limitations associated with these conditions, and also produces time and cost savings."