Dr Roja Rahimi and colleagues from Iran systematically evaluated the efficacy of antibacterial therapy in ulcerative colitis.
The research team carried out a meta-analysis of controlled clinical trials from 1966 through September 2006.
PUBMED, EMBASE, and SCOPUS were searched for clinical trial studies that investigated the efficacy of antibiotics in ulcerative colitis.
|The odds ratio in favor of antimicrobial therapy was 2.1|
|Digestive Diseases and Sciences|
The team considered clinical remission as their key outcome of interest.
Of 122 studies, 10 randomized placebo-controlled clinical trials including 530 patients matched their criteria, and were included in the analysis.
All the studies used antibiotics as an adjunct therapy to conventional treatment of ulcerative colitis.
The team found on pooling the results of these trials, that the odds ratio in favor of antimicrobial therapy was 2.1.
Meta-analysis of short-term trials showed a higher rate of clinical remission in patients treated with antibiotics.
Dr Rahimi's team concluded, "These results suggest that adjunctive antibacterial therapy is effective for induction of clinical remission in ulcerative colitis."