Dr Uma Mahadevan and colleagues from California, USA determined whether pregnancy outcomes differ between women with and without inflammatory bowel disease (IBD).
The investigative team determined what risk factors adversely affect outcomes.
The team conducted a cohort study of all pregnant women within the Northern California Kaiser Permanente membership between the years 1995 and 2002.
The team abstracted the records of all pregnancies in 461 women with IBD.
|A diagnosis of IBD was an independent predictor of an adverse outcome|
The investigators also assessed a random sample of pregnancies from 493 age-matched women without IBD.
The team evaluated risk factors for spontaneous abortion, complications of pregnancy, and adverse newborn events.
Women with IBD were more likely to have an adverse conception outcome, an adverse pregnancy outcome, or a pregnancy complication.
However, the team noted that the difference between the 2 groups in adverse newborn outcomes was not statistically significant.
Independent predictors of an adverse outcome included a diagnosis of IBD, a history of surgery for IBD, and non-Caucasian ethnicity.
The investigators observed that severity of disease and medical treatments were not associated with an adverse outcome.
Dr Mahadevan's team concluded, "Women with IBD are more likely to have an adverse outcome related to pregnancy."
"Disease activity and medical treatment did not predict adverse outcomes in a large, nonreferral population."