Standard triple therapies are the most used treatment in clinical practice.
However, a critical fall in the Helicobacter pylori eradication rate following these therapies has been observed in the last few years.
The sequential regimen is a novel, promising therapeutic approach.
Dr Angelo Zullo and colleagues from Italy evaluated the available data on the sequential therapy regimen.
|Sequential treatment regimen achieves higher eradication rates than standard therapies|
The team performed a pooled-data analysis of all studies on the sequential regimen.
The eradication rate was calculated according to gastroduodenal pathology, proton pump inhibitor used, antibiotic resistance, as well as clinical setting.
Compliance, side effects, and cost implications were also evaluated.
The researchers noted that, overall, more than 1800 patients have been treated with the sequential regimen.
The team found that such a therapy was superior to 7 to 10 days triple therapies in paediatric, adult and elderly patients.
The therapy achieved an eradication rate constantly higher than 90% at intention-to-treat analysis.
The team noted that primary clarithromycin resistance reduced the efficacy of such a therapy.
However, the success rate was significantly higher than that observed with the standard 7 to 10 days triple therapies.
Dr Zullo's team concluded, "The 10-day sequential treatment regimen achieves higher eradication rates than standard triple therapies."