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News

Gene variations found in Crohn's disease patients

October's issue of Inflammatory Bowel Diseases evaluates the role of the genetic variations of PTPN22, NFKB1, and FcGRIIIA genes in IBD.

News image

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Dr Vito Annese and colleagues from Italy tested several polymorphisms of genes involved in the mucosal immune system in a population of inflammatory bowel disease (IBD) patients.

The researchers investigated the possible implication of the polymorphisms in disease predisposition.

Genotype frequencies of the G559T allele of the FcGRIIIA gene were different in Crohn's
Inflammatory Bowel Diseases

The team investigated polymorphisms of 3 candidate genes, including PTPN22, NFkB1, and FcGRIIIA in 649 inflammatory bowel disease patients.

Of these, 343 had Crohn's disease, 306 had ulcerative colitis, 176 had unaffected relatives, and 256 were healthy controls.

Allele and genotype frequencies were correlated with clinical characteristics and major variants of the CARD15 gene.

The team's findings were pooled in a meta-analysis with the available studies in the literature.

The researchers found no significant difference for the PTPN22 and NFkB1 variants.

In contrast, allele and genotype frequencies of the G559T allele of the FcGRIIIA gene were significantly different in Crohn's disease patients compared to controls.

However, the researchers did not confirm any significant overtransmission of the T allele at the family-based analysis.

For all genes, neither an interaction with CARD15 gene, nor a significant difference at genotype/phenotype analysis was demonstrated, including response to medical therapy.

Dr Annese's team concluded, "Although involved in autoimmune diseases, the PTPN22 and NFkB1 genes do not seem involved in the inflammatory bowel disease predisposition, also according to meta-analysis results."

"The association with the G559T polymorphism of the FcGRIIIA gene in Crohn's disease patients deserves further investigation."

Inflamm Bowel Dis 2007: 13(10): 1212-9
18 September 2007

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