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 24 January 2018

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News

Serum CRP levels predict survival in hepatocellular carcinoma

The latest issue of Liver International finds that serum C-reactive protein levels predict survival in hepatocellular carcinoma.

News image

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C-reactive protein was recently identified as a prognostic factor for patients with hepatocellular carcinoma after surgical resection.

Dr Sakae Nagaoka and colleagues from Japan investigated the relationship between the serum levels of high sensitivity C-reactive protein (CRP) and the prognosis of hepatocellular carcinoma patients.

The prognosis of C-reactive protein-positive patients was poorer
Liver International

The team conducted a cohort study of 90 hepatocellular carcinoma patients enrolled from 1997 to 1998.

All patients were treated and followed for a mean period of 3 years.

Clinical variables were compared between 47 patients positive for C-reactive protein, and 43 patients negative for C-reactive protein.

The team also determined the relationship between serum C-reactive protein and prognosis in hepatocellular carcinoma patients.

The researchers found the survival rate of patients of the C-reactive protein-positive group was lower than that of C-reactive protein-negative patients.

The team noted that tumor stages 3 or 4, total bilirubin of 1.2 mg/dL, albumin less than 3.5 g/dL, and des-gamma-carboxy prothrombin of 40 mAU/mL were poor prognostic indicators.

Positive C-reactive protein and initial treatment were identified as significant poor prognostic factors by univariate analysis.

Using multivariate Cox proportional hazard analysis, C-reactive protein, albumin less than 3.5 g/dL, tumor stage and initial treatment were considered to be significant determinants of poor prognosis.

Dr Nagaoka's team concluded, "The prognosis of C-reactive protein-positive patients was poorer compared with C-reactive protein-negative patients."

"This study confirmed that C-reactive protein is a marker of poor prognosis in hepatocellular carcinoma patients."

Liver Int 2007: 27(8): 1091-7
11 September 2007

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