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News

Crohn's disease increases the risk of preterm births

This month's American Journal of Gastroenterology reports on a regional cohort study of disease activity and birth outcomes in pregnant women with Crohn's.

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Crohn's disease is associated with increased risk of adverse birth outcomes.

However, existing studies have not assessed the impact of disease activity during pregnancy.

Dr Bente Nørgård and colleagues from Denmark examined the impact of disease activity on birth outcomes such as low birth weight, preterm birth, low birth weight at term, and CAs.

The risk of preterm birth was 3.4 with moderate to high disease activity
The American Journal of Gastroenterology

The team evaluated all births by women with Crohn's disease in North Jutland County, Denmark from 1977 to 2005.

The research team undertook a cohort study based on linkage between the Danish National Registry of Patients and the Medical Birth Registry.

After identification of all births by CD women, review of medical records allowed collection of clinical details.

The exposed cohort constituted 71 women with pregnancies with low/moderate-high disease activity during pregnancy.

The unexposed cohort included 86 women with inactive disease.

The team used logistic regression analyses to estimate the adjusted relative risk for adverse birth outcomes associated with disease activity in Crohn's disease pregnancies.

In subanalysis, the researchers examined the impact of moderate to high activity.

The researchers found that in women with disease activity, the adjusted risks of low birth weight, and low birth weight at term were 0.2, and 0.4, respectively.

The adjusted risks of preterm birth, and CAs were 2.4, and 0.8, respectively.

The team observed that the crude risk of preterm birth was 3.4 in those with moderate to high disease activity.

Dr Nørgård's team concluded, "Disease activity during pregnancy only increased the risk of preterm birth, especially in those with high disease activity."

"Further research is needed to assess the critical impact of disease activity in larger cohorts of Crohn's disease women."

Am J Gastroenterol 2007: 102(9): 1947-54
03 September 2007

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