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News

Methods for improving 24-hour esophageal pH monitoring

The 24-hour esophageal pH monitoring should be divided to awake and asleep rather than upright and supine time periods, finds September's Neurogastroenterology & Motility.

News image

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Esophageal acid exposure analysis is divided to upright and supine.

This is based on the assumption that the supine-awake period is similar to the supine-asleep period.

Dr Ronnie Fass and colleagues from Arizona, USA determined if the principal acid-reflux characteristics of supine-awake are closer to supine-asleep or upright period.

The frequency of acid-reflux events was higher in both upright and supine-awake periods
Neurogastroenterology & Motility

Patients with heartburn underwent an upper endoscopy and pH testing.

The team instructed the patients to carefully document their upright, supine-awake and supine-asleep periods.

A total of 64 patients were enrolled into this study, of which 35 were male with a mean age of 52 years.

The research team found that the mean percentage total time of a pH less than 4 was not different between upright and the supine-awake period.

Frequency of acid-reflux events per hour, and number of sensed reflux events was not different between upright and the supine-awake period .

The team found in contrast, that the mean percentage total time of pH less than 4 was significantly higher in both upright and supine-awake periods vs supine-asleep.

In addition, the frequency of acid-reflux events and number of sensed reflux events was higher in both upright and supine-awake periods vs supine-asleep.

Dr Fass' team concluded, "The principal characteristics of the acid-reflux events in the supine-awake period are closer to the upright period than to the supine-asleep period."

Neurogastroenterol Motility 2007: 19(9): 709-15
03 September 2007

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