Anorectal malformations appeared to be increasing in the province of Alberta, Canada.
Dr Brian Lowry and colleagues from Canada assessed whether this was a significant trend, with the possibility of these having a teratogenic origin.
The investigative team examined the frequency of anorectal malformations over a 15-year period.
The team examined the records of the Alberta Congenital Anomaly Surveillance System.
|Approximately 75% of the 273 cases had 1 or more malformation|
|Journal of Pedeatric Surgery|
This system is a semiactive surveillance system using the British Pediatric Association, the Royal College of Pediatrics and Child Health expansions of the International Classification of Diseases-9th Revision and the International Classification of Diseases-10th Revision.
The team found that the overall rate was 1 in 2162, or 5 per 10,000 total births.
The investigators observed a marked male predominance of 2:1.
Approximately 75% of the 273 cases had 1 or more malformation.
Dr Lowry's team concluded, "Although there was an increasing trend in the rate from 1999 especially for the multiples, this was not significant."
"In view of the advances in syndrome identification and molecular diagnostics, consideration should be given to a detailed review of the family history and appropriate testing not only for multiple cases, but also for isolated ones."