Obesity has been associated with increased risk for colorectal adenoma.
However, its role as a risk factor after polypectomy for recurrence is unclear.
Dr Elizabeth Jacobs and colleagues from Arizona, USA evaluated the effect of anthropometric measures of obesity on adenoma after polypectomy.
The team inducted 2465 subjects with baseline adenomas.
The team drew follow-up colonoscopy data from 2 randomized trials designed to prevent adenoma recurrence over a mean follow-up period of 3 years.
|Obesity is a risk factor for colorectal adenomas among men|
|Clinical Gastroenterology & Hepatology|
The team found that a body mass index of 30 kg/m2 was associated with a nonsignificant 17% increase in the odds for any adenoma recurrence among all subjects.
This result was confined to men, and not observed for women.
The researchers found that waist circumference did not reach statistical significance, although trends were similar to those for body mass index.
Analyses of the effects of obesity on more clinically significant lesions demonstrated that high body mass index was a stronger risk factor for advanced adenoma recurrences in men.
The team observed an association for obesity and odds of adenoma recurrence among participants reporting a family history of colorectal cancer.
However, the team did not note an association for obesity and odds of adenoma recurrence in participants without a family history of colorectal cancer.
Dr Jacobs' team concluded, "Our results support obesity as a risk factor for subsequent short-interval development of colorectal adenomas, particularly among men and persons with a family history of colorectal cancer."
"Furthermore, obesity in men appears to be strongly associated with the development of clinically advanced lesions."