Dr Chien-Jen Chen and colleagues from Taiwan determined the risk of all-cause and cause-specific mortality.
The research team examined the predictors of mortality in chronic Hepatitis B infection.
The team performed a prospective cohort study of 23,820 persons.
|Hep B surface antigen gave higher hazard ratios for all causes of mortality|
|Clinical Gastroenterology & Hepatology|
The patients were recruited between 1991 and 1992 and followed up through 2004 from 7 townships in Taiwan.
The team found that the main outcomes were all-cause and liver-related mortality rates.
Mortality analyses used time-to-events methods, and survival curves were derived by the Kaplan-Meier method.
The researchers used cox proportional hazard models to estimate multivariable-adjusted hazard ratios.
The team found there were 1814 deaths during a mean follow-up period of 13 years.
Persons positive for Hepatitis B surface antigen had significantly higher adjusted hazard ratios for all causes of mortality.
Liver cancer mortality, and chronic liver disease and cirrhosis mortality also resulted in higher adjusted hazard ratios in persons positive for Hepatitis B surface antigen.
When compared with Hepatitis B surface antigen-negative persons, persons with Hepatitis B virus DNA levels less than 104 had a high risk of hepatocellular carcinoma mortality.
The team observed that in Hepatitis B surface antigen-positive persons, the mortality rate increased with cohort entry serum Hepatitis B virus DNA level.
The researchers observed that liver cancer mortality was 73 per 100,000 person-years for subjects with Hepatitis B virus DNA levels less than 300 copies/mL.
The research team noted that liver cancer mortality was 816 per 100,000 person-years for those with Hepatitis B virus DNA levels of 1 million copies/mL or greater.
Chronic liver disease and cirrhosis deaths ranged from 9 to 267 per 100,000 person-years.
Dr Chen's team concluded, "Chronic Hepatitis B virus infection is associated with significant preventable excess mortality risk."
"This mortality risk is correlated strongly with the level of viral replication among other factors."