Many patients with Crohn's disease complain of abdominal discomfort after alcohol intake.
Dr Henrik Hey and colleagues from Denmark investigated the effect of ethanol and sugar content in 5 different alcoholic drinks on abdominal discomfort in patients with Crohn's disease.
The team conducted a crossover study, 2 weeks apart, of 12 healthy individuals and 20 patients with Crohn's disease in remission.
The patients randomly consumed red wine, white wine, Smirnoff Ice, Elephant Beer and pure ethanol.
|Smirnoff Ice intake increases self-reported abdominal pain|
|Scandinavian Journal of Gastroenterology|
Blood samples were obtained for determination of serum ethanol and plasma glucose at 0, 30, 60, 90, 120 and 180 minutes.
The team used a self-reported pain symptom score.
The team found there was no difference between patients with Crohn's and healthy individuals in the area under the curve for the ethanol concentration after intake of the 5 different drinks.
The researchers noted that the plasma area under the curve for glucose in the Crohn's disease patients after intake of Smirnoff Ice and Elephant beer was increased.
Abdominal pain manifestations were significantly more pronounced in Crohn's disease patients following intake of Smirnoff Ice and Elephant beer.
Dr Hey's team concluded, "The present study shows no difference in alcohol absorption between Crohn's disease patients and controls."
"The alcoholic drinks Smirnoff Ice and Elephant beer have an increased effect on self-reported abdominal pain in Crohn's disease patients, probably due to the high sugar content in these drinks."