Dr Eva Romo and colleagues assessed whether end-stage liver failure modifies peripheral blood lymphocytes in a homogeneous manner, independent of the base pathology.
The team also investigated if, on the contrary, peripheral blood lymphocytes subsets show a different profile in each hepatic disease.
The team studied peripheral blood lymphocytes subsets in 71 patients with end-stage liver disease, before liver transplant, and 74 healthy controls by flow cytometry.
The team statistically compared patients and controls, and cohorts of patients classified according to their base pathology.
The researchers observed lower absolute numbers in all lymphocyte populations in patients compared with controls.
|Alcoholic cirrhotic patients showed low CD8+|
|Journal of Clinical Gastroenterology|
The team found an increment of CD3+ activated cells in chronic Hepatitis C virus patients versus controls.
In addition, the research team noted an increment of CD45RO+CD4+ in chronic Hepatitis C virus patients versus controls.
Hepatitis B virus showed high TCR[gamma][delta]+ and CD8+ T cells with respect to controls.
The team found that alcoholic cirrhotic patients showed low CD8+, mainly CD45RA+CD8+, and high CD45RO+CD4+.
The team found that, compared with the normal population, autoimmune diseases showed lower CD3+ and TCR[alpha][beta]+ than controls.
Dr Romo's team concluded, "Regardless of the base pathology, patients with end-stage liver disease show a low absolute number of lymphocyte populations compared with controls."
"However, peripheral blood lymphocytes profiles are different, characteristic, and specific of every disease causing chronic liver failure."