Dr Crozier and colleagues evaluated the relationship between the preoperative and postoperative systemic inflammatory response and survival in patients undergoing potentially curative resection for colorectal cancer.
The team of doctors studied 180 patients with colorectal cancer.
Circulating concentrations of C-reactive protein (CRP) were measured before surgery and in the immediate postoperative period.
The peak in C-reactive protein concentration occurred on day 2.
The team reported that during the course of the study 59 patients died, 30 from cancer and 29 from intercurrent disease.
|A raised preoperative CRP level was associated with poorer cancer-specific survival|
|British Journal of Surgery|
Day 2 C-reactive protein concentrations were dichotomized.
Using univariable analysis, the researchers found that advanced tumor node metastasis stage was associated with poorer cancer-specific survival.
The doctors noted that a raised preoperative C-reactive protein level was also associated with poorer cancer-specific survival.
In addition, the team observed that the presence of hypoalbuminaemia was associated with poorer cancer-specific survival.
Dr Crozier's team comments, "Preoperative but not postoperative C-reactive protein concentrations are associated with poor tumor-specific survival in patients undergoing potentially curative resection for colorectal cancer."